Number of patients treated |
Escalate if # of DLT <= |
Deescalate if # of DLT >= |
Eliminate if # of DLT >= |
|---|---|---|---|
3 |
0 |
2 |
3 |
6 |
1 |
3 |
4 |
9 |
2 |
4 |
5 |
12 |
2 |
5 |
7 |
15 |
3 |
6 |
8 |
18 |
4 |
7 |
9 |
21 |
4 |
8 |
10 |
24 |
5 |
9 |
11 |
27 |
6 |
10 |
12 |
30 |
7 |
11 |
14 |
Comments on the case study
For the actual project, we explored other scenarios and questions (results not shown)
What happens if we targeted a higher DLT rate (e.g., 0.200 instead of 0.150)
Different cohort sizes: 3, 6, and 9
Different number of cohorts: 10, 15, and 20